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Scientist III/IV, Molecular Pathology

Company: Boehringer Ingelheim
Location: Ridgefield
Posted on: June 25, 2022

Job Description:

Description:Scientist III/IVCandidate will be hired at level commensurate with experience The Molecular Pathology group within Non-clinical Drug Safety (NDS) for Development at Boehringer Ingelheim is seeking a talented scientist to join their team at the Ridgefield, CT, site. The Molecular Pathology laboratory uses state-of-the-art methods integrating histopathology with current molecular and imaging techniques. The primary function of the team is to provide tissue-based biomarker data in support of drug safety decisions, with a focus on New Biological Entities and Advanced Therapy Medicinal Products including oncolytic viruses.The main responsibility of this position is to develop and apply methods for molecular pathology endpoints. Major assay types will include immunohistochemistry (IHC) and in situ hybridization (ISH). Key portfolio deliverables are tissue cross-reactivity, target tissue distribution, and mechanistic studies. Elements of this work include scheduling and securing needed reagents, interfacing with other research, histology, and toxicology teams, transferring methods for Good Laboratory Practice (GLP) studies, facilitating collaborations with key partners, presenting results to study teams, and preparing technical reports for molecular pathology studies.General expectations for this role are to perform routine lab duties with minimal supervision, participate/assist in the design and execution of non-routine experiments, coordinate molecular pathology studies, communicate results to team leads, and perform all work in a safe manner and in conformance with applicable regulations. The scope of responsibility is primarily within the laboratory environment and immediate discipline.As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development, and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employeesDuties & Responsibilities\:

  • Coordinate and conduct target tissue distribution studies - Oversee ordering and validation of antibodies and control reagents; optimize and troubleshoot IHC and ISH assays as needed, including chromogenic and fluorogenic formats; work with project pathologists to characterize target expression; and write methods for study reports.
    • Develop and transfer methods for tissue cross-reactivity studies - Ensure all needed reagents, tissues, and control materials are ordered and received in a timely fashion; oversee labeling and characterization of reagents as needed; conduct IHC assays and confirm that methods are optimized and fit-for-purpose; review immunolabeling with project pathologists; and write method development reports for transfer to Contract Research Organizations.
      • Develop and implement new assays and biomarkers - Develop, conduct, and optimize novel tissue -based assays; support use of enhanced safety or mechanistic endpoints in NDS non-clinical safety evaluations; and propose new assays, techniques, or approaches based on current information.
        • Document work activities and study records completely and accurately - Maintain records for all laboratory work in accordance with study protocols by following applicable company policies, using current forms and procedures, and making all entries legibly, correctly and contemporaneously; and perform all work safely and in compliance with all applicable regulations, standard operating procedures, company policies, safety training and procedures.
          • Initiate and complete routine laboratory procedures in an independent and efficient manner, with minimal supervision, and independently operate and manage laboratory equipment.
            • Demonstrate technical ability to assist in the design, execution, and troubleshooting of non-routine experiments with limited supervision.
              • Apply basic scientific principles with minimal guidance; performs literature searches and extracts relevant information from published protocols.
                • Demonstrate the ability to interpret outcome of experiments and to propose appropriate follow-up work.
                  Scientist III Requirements\:
                  • Bachelor's Degree from an accredited institution with 7+ years of experience in a relevant scientific discipline; or Master's Degree from an accredited institution with six-plus (3+) years of experience in a relevant scientific discipline
                    Scientist IV Requirements\:
                    • Bachelor's Degree from an accredited institution with 10+ years of experience in a relevant scientific discipline; or Master's Degree from an accredited institution with 6+ years of experience in a relevant scientific disciplineOther Requirements\:
                      • Hands on experience in assay development and optimization, data analysis and interpretation.
                        • Knowledge and experience in the principles and approaches for development of Immunohistochemistry (IHC), in situ hybridization (ISH) assays
                          • Knowledge and experience in the principles and approaches for development of antibody reagent characterization, cataloging
                            • Laboratory management experiencePreferred Experience\:
                              • Familiarity or experience with Retrogenix Cell Microarray Technology a plus. Work with our Discovery organization to support the selection of lead molecules or the characterization off-target toxicities within Development.
                              • Digital imaging experience with commercial image analysis software such as Definiens, Visiopharm, HALO, or other platforms. The successful candidate will support image analysis by generating scanned whole slide images of tissues labeled with various molecular pathology techniques (IHC, ISH, IF) to quantify cellular and tissue morphologic endpoints. Projects will be conducted in collaboration with a software programmer to run machine learning and deep learning algorithms.Eligibility Requirements\:
                                • Must be legally authorized to work in the United States without restriction.
                                • Must be willing to take a drug test and post-offer physical (if required).
                                • Must be 18 years of age or older.
                                • This position will require individuals to be fully vaccinated against COVID-19 or have an approved medical or religious accommodation. Click here for more information on the vaccine mandate and COVID-19.Who We Are\:At Boehringer Ingelheim we create value through innovation with one clear goal\: to improve the lives of patients. We develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family-owned company, we focus on long term performance. We are powered by 50.000 employees globally who nurture a diverse, collaborative, and inclusive culture. Learning and development for all employees is key because your growth is our growth.Want to learn more? Visit boehringer-ingelheim.com and join us in our effort to make more health.Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment, which benefits our employees, patients and communities. All qualified applicants will receive consideration for employment without regard to a person's actual or perceived race, including natural hairstyles, hair texture and protective hairstyles; color; creed; religion; national origin; age; ancestry; citizenship status, marital status; gender, gender identity or expression; sexual orientation, mental, physical or intellectual disability, veteran status; pregnancy, childbirth or related medical condition; genetic information (including the refusal to submit to genetic testing) or any other class or characteristic protected by applicable law

Keywords: Boehringer Ingelheim, New England , Scientist III/IV, Molecular Pathology, Healthcare , Ridgefield, Northeast

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