Scientist III/IV, Molecular Pathology
Company: Boehringer Ingelheim
Location: Ridgefield
Posted on: June 25, 2022
Job Description:
Description:Scientist III/IVCandidate will be hired at level
commensurate with experience The Molecular Pathology group within
Non-clinical Drug Safety (NDS) for Development at Boehringer
Ingelheim is seeking a talented scientist to join their team at the
Ridgefield, CT, site. The Molecular Pathology laboratory uses
state-of-the-art methods integrating histopathology with current
molecular and imaging techniques. The primary function of the team
is to provide tissue-based biomarker data in support of drug safety
decisions, with a focus on New Biological Entities and Advanced
Therapy Medicinal Products including oncolytic viruses.The main
responsibility of this position is to develop and apply methods for
molecular pathology endpoints. Major assay types will include
immunohistochemistry (IHC) and in situ hybridization (ISH). Key
portfolio deliverables are tissue cross-reactivity, target tissue
distribution, and mechanistic studies. Elements of this work
include scheduling and securing needed reagents, interfacing with
other research, histology, and toxicology teams, transferring
methods for Good Laboratory Practice (GLP) studies, facilitating
collaborations with key partners, presenting results to study
teams, and preparing technical reports for molecular pathology
studies.General expectations for this role are to perform routine
lab duties with minimal supervision, participate/assist in the
design and execution of non-routine experiments, coordinate
molecular pathology studies, communicate results to team leads, and
perform all work in a safe manner and in conformance with
applicable regulations. The scope of responsibility is primarily
within the laboratory environment and immediate discipline.As an
employee of Boehringer Ingelheim, you will actively contribute to
the discovery, development, and delivery of our products to our
patients and customers. Our global presence provides opportunity
for all employees to collaborate internationally, offering
visibility and opportunity to directly contribute to the companies'
success. We realize that our strength and competitive advantage lie
with our people. We support our employees in a number of ways to
foster a healthy working environment, meaningful work, diversity
and inclusion, mobility, networking and work-life balance. Our
competitive compensation and benefit programs reflect Boehringer
Ingelheim's high regard for our employeesDuties &
Responsibilities\:
- Coordinate and conduct target tissue distribution studies -
Oversee ordering and validation of antibodies and control reagents;
optimize and troubleshoot IHC and ISH assays as needed, including
chromogenic and fluorogenic formats; work with project pathologists
to characterize target expression; and write methods for study
reports.
- Develop and transfer methods for tissue cross-reactivity
studies - Ensure all needed reagents, tissues, and control
materials are ordered and received in a timely fashion; oversee
labeling and characterization of reagents as needed; conduct IHC
assays and confirm that methods are optimized and fit-for-purpose;
review immunolabeling with project pathologists; and write method
development reports for transfer to Contract Research
Organizations.
- Develop and implement new assays and biomarkers - Develop,
conduct, and optimize novel tissue -based assays; support use of
enhanced safety or mechanistic endpoints in NDS non-clinical safety
evaluations; and propose new assays, techniques, or approaches
based on current information.
- Document work activities and study records completely and
accurately - Maintain records for all laboratory work in accordance
with study protocols by following applicable company policies,
using current forms and procedures, and making all entries legibly,
correctly and contemporaneously; and perform all work safely and in
compliance with all applicable regulations, standard operating
procedures, company policies, safety training and procedures.
- Initiate and complete routine laboratory procedures in an
independent and efficient manner, with minimal supervision, and
independently operate and manage laboratory equipment.
- Demonstrate technical ability to assist in the design,
execution, and troubleshooting of non-routine experiments with
limited supervision.
- Apply basic scientific principles with minimal guidance;
performs literature searches and extracts relevant information from
published protocols.
- Demonstrate the ability to interpret outcome of experiments and
to propose appropriate follow-up work.
Scientist III Requirements\:
- Bachelor's Degree from an accredited institution with 7+ years
of experience in a relevant scientific discipline; or Master's
Degree from an accredited institution with six-plus (3+) years of
experience in a relevant scientific discipline
Scientist IV Requirements\:
- Bachelor's Degree from an accredited institution with 10+ years
of experience in a relevant scientific discipline; or Master's
Degree from an accredited institution with 6+ years of experience
in a relevant scientific disciplineOther Requirements\:
- Hands on experience in assay development and optimization, data
analysis and interpretation.
- Knowledge and experience in the principles and approaches for
development of Immunohistochemistry (IHC), in situ hybridization
(ISH) assays
- Knowledge and experience in the principles and approaches for
development of antibody reagent characterization, cataloging
- Laboratory management experiencePreferred Experience\:
- Familiarity or experience with Retrogenix Cell Microarray
Technology a plus. Work with our Discovery organization to support
the selection of lead molecules or the characterization off-target
toxicities within Development.
- Digital imaging experience with commercial image analysis
software such as Definiens, Visiopharm, HALO, or other platforms.
The successful candidate will support image analysis by generating
scanned whole slide images of tissues labeled with various
molecular pathology techniques (IHC, ISH, IF) to quantify cellular
and tissue morphologic endpoints. Projects will be conducted in
collaboration with a software programmer to run machine learning
and deep learning algorithms.Eligibility Requirements\:
- Must be legally authorized to work in the United States without
restriction.
- Must be willing to take a drug test and post-offer physical (if
required).
- Must be 18 years of age or older.
- This position will require individuals to be fully vaccinated
against COVID-19 or have an approved medical or religious
accommodation. Click here for more information on the vaccine
mandate and COVID-19.Who We Are\:At Boehringer Ingelheim we create
value through innovation with one clear goal\: to improve the lives
of patients. We develop breakthrough therapies and innovative
healthcare solutions in areas of unmet medical need for both humans
and animals. As a family-owned company, we focus on long term
performance. We are powered by 50.000 employees globally who
nurture a diverse, collaborative, and inclusive culture. Learning
and development for all employees is key because your growth is our
growth.Want to learn more? Visit boehringer-ingelheim.com and join
us in our effort to make more health.Boehringer Ingelheim is an
equal opportunity global employer who takes pride in maintaining a
diverse and inclusive culture. We embrace diversity of perspectives
and strive for an inclusive environment, which benefits our
employees, patients and communities. All qualified applicants will
receive consideration for employment without regard to a person's
actual or perceived race, including natural hairstyles, hair
texture and protective hairstyles; color; creed; religion; national
origin; age; ancestry; citizenship status, marital status; gender,
gender identity or expression; sexual orientation, mental, physical
or intellectual disability, veteran status; pregnancy, childbirth
or related medical condition; genetic information (including the
refusal to submit to genetic testing) or any other class or
characteristic protected by applicable law
Keywords: Boehringer Ingelheim, New England , Scientist III/IV, Molecular Pathology, Healthcare , Ridgefield, Northeast
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